The Seattle Intensivist’s Blog
An Even More Skeptical Guide to Vitamin C in Sepsis
Since the first publication of vitamin C for sepsis, several randomized controlled trials have been completed, and more are ongoing. I review the 6 large RCTs and provide a meta-analysis. (Spoiler alert: it doesn’t look good for the “metabolic cure.”)
A Skeptic’s Guide to Vitamin C in Sepsis
Since the first publication of vitamin C for sepsis, several randomized controlled trials have been completed, and more are ongoing. I review the 6 large RCTs and provide a meta-analysis. (Spoiler alert: it doesn’t look good for the “metabolic cure.”)
Is Critical Care becoming a Cargo Cult of Vitamin C?
Dozens of institutions have embraced the “metabolic cure” based upon evidence far flimsier than would be required for any “non-natural” medicine. Non-falsifiable theories ("this patient was saved by vitamin C”) are proffered as fact.
Whether the “metabolic cure” is truly a panacea or not remains to be rigorously tested. Whatever the outcome, the rituals practiced by the cargo cult of critical care must be questioned. Surely, if a plane did land on an Atoll, it was not brought there by magic.